At a Glance

Scientists show effectiveness of carrot-based Japanese herbal medicine called “Ninjin’yoeito” in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal "International Journal of Chronic Obstructive Pulmonary Disease" on November 27, 2020.

Summary

Chronic obstructive pulmonary disease (COPD) is a lung disease caused by long-term inhalation of harmful gases such as cigarette smoke. Scientists have recognized deterioration of muscle tissue, known as, as a secondary effect of damaged lungs. This frailty makes it difficult for individuals to move around and exercise, which is turn worsens the state of their lungs, causing an endless downward spiral in overall health. 

Exercise therapy is the only established treatment for the skeletal muscle complications of COPD, however, depending on the severity of sarcopenia frailty in the patient, such treatment may not be possible. This imbalance has become an urgent issue to address. Ninjin’yoeito is a carrot-based Japanese herbal medicine commonly given to people recovering from anorexia and physical weakness after illness or surgery for its supplementary effect in restoring physical strength. Also, the medicine has been seen to improve muscle mass loss in aging mice through the activation of PGC-1α- a protein involved in improving muscle function. 

“Based on this, we hypothesized that Ninjin’yoeito enhances PGC-1α expression in skeletal muscle and may improve muscle complications associated with COPD”, explains Associate Professor Kazuhisa Asai from the Osaka City University Graduate School of Medicine. He led a research group in testing this hypothesis by including Ninjin’yoeito in the diet of mice who had been exposed to cigarette smoke for 12 weeks. His team measured the lower leg muscle mass of the smoke-exposed group of mice with a microCT and noticed they had atrophied, like human COPD patients. However, he saw no such change in muscle mass with the experimental group of mice, suggesting that the addition of the carrot-rich medicine cancels out the effects of sarcopenia frailty.  

“We believe that this is a useful finding and that Ninjin’yoeito may break the vicious circle of sarcopenia frailty in COPD patients”, adds Associate Professor Asai. “We would like to consider clinical trials in the future.”

Publication Information

Paper title : "Ninjin’yoeito ameliorates skeletal muscle complications in COPD model mice by upregulating peroxisome proliferator-activated receptor γ coactivator-1α expression"

Journal : International Journal of Chronic Obstructive Pulmonary Disease, 27 November 2020 Volume 2020:15 Pages 3063—3077

Authors : Miyamoto A, Asai K, Kadotani H, Maruyama N, Kubo H, Okamoto A, Sato K, Yamada K, Ijiri N, Watanabe T, Kawaguchi T

URL : https://www.dovepress.com/ninjinrsquoyoeito-ameliorates-skeletal-muscle-complications-in-copd-mo-peer-reviewed-article-COPD

Funding

This work was partially supported by JSPS KAKENHI (Grant-in-Aid for Scientific Research (C)) Grant Number 19K08660.